![]() I have not used it with an FET cycle (because it is more expensive), but it can work just as well with the protocol you have outlined. I think the change to an "antagonist" is certainly the best way to go. I converted to using the antagonist, Cetrotide and now Ganerelix, over 5 years ago (mainly because it is less injections). Since you have been using GnRH "agonists (stimulators)" in your previous cycles, it sounds like maybe the dosages were not high enough to suppress the hypothalamus (which is what they are supposed to do and prevent ovarian function), but instead stimulated FSH production and ovarian stimulation leading to the OHSS. If not, your docs might want to write your case up as an unusual case. I'll have to do some research on that and see if that actually happens. I have never heard of such as thing as OHSS with an FET cycle. Thank you so much for reading and for any input you may be able to give! G. ![]() My subsequent two transfers resulted in a negative beta. I also got pg on our first FET with twins, which I sadly miscarried at 8 weeks. If you were my Dr (I wish you were :D ), what protocol would you suggest for a FET? It may be helpful to add that I have always been a slim PCOSer (BMI 21) and have an AMH of 98.5. Is this likely to happen with the Cetrotide at all? Have you had any PCOS patients who have ever responded like I have to suppression medications? I am terrified of hyperstimulating again. All in all, this protocol should only take around 13days, then I would commence Progesterone, 3-4days before Embryo Transfer. On Day 5, I would commence daily Cetrotide shots, whilst continuing daily with the Progynova. On day 3 of my period, I would inject a long acting Cetrotide shot (sub-q) and also commence 6mg Progynova (estradiol valerate). The new protocol would not involve the usual suppression medications. I am naturally frightened and sceptical about this new protocol since it hasn't been tried and tested in the UK as yet (but apparently it has in other countries with good success for challenging PCOS patients). My treatment is in the UK and I cannot switch clinics b/c a) my treatment is free and b) since it's free I can't choose where to have my IVF/FET's. The Drs at my clinic have put their heads together to try to come up with an individualized protocol for me, since I keep suffering these rare responses to the suppression meds. I have gone through six FET cycles since, but only got to transfer three times, b/c the drugs used to suppress my ovaries (ProstapSR, Buserelin, Synarel) have actually stimulated my ovaries, leading to OHSS a further three times! We had 13 embryos, all of which were frozen at the 2PN stage. On my fresh cycle in 2008, I had 30 eggs retrieved and due to OHSS, couldn't have an Embryo Transfer. My husband has severe m/f, so our only chance of conceiving is through IVF with ICSI. Firstly, thank you so much in advance for taking the time to read my question.īrief History: Dx with PCOS at 17 y/o.
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